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Advances in hyaluronic acid production: Biosynthesis and genetic engineering strategies based on Streptococcus - A
Mengmeng Wei1, Ying Huang1, Junyuan Zhu1
1College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310000, PR China.
Abstract:
Hyaluronic acid (HA), which is a highly versatile glycosaminoglycan, is widely applied across the fields of food, cosmetics, and pharmaceuticals. It is primary produced through Streptococcus fermentation, but the product presents inherent challenges concerning consistency and potential pathogenicity. However, recent strides in molecular biology have paved the way for genetic engineering, which facilitates the creation of high-yield, nonpathogenic strains adept at synthesizing HA with specific molecular weights. This comprehensive review extensively explores the molecular biology underpinning pivotal HA synthase genes, which elucidates the intricate mechanisms governing HA synthesis. Moreover, it delineates various strategies employed in engineering HA-producing strains.
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