Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elastase-alpha 1 antitrypsin complexes in acute leukaemia.

M J Galloway, M J Mackie, B A McVerry

    Thrombosis Research
    |May 15, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An audit of the implementation of the international consensus group's guidelines on reporting of blood films.

    Journal of clinical pathology·2010
    Same author

    A tabletop exercise to assess a hospital emergency blood management contingency plan in a simulated acute blood shortage.

    Transfusion medicine (Oxford, England)·2008
    Same author

    The addition of oral idarubicin to a chlorambucil/dexamethasone combination has a significant impact on time to treatment failure but none on overall survival in patients with low grade non-Hodgkin's lymphoma: Results of the Scotland and Newcastle Lymphoma Group randomized NHL VIII trial.

    Leukemia & lymphoma·2006
    Same author

    Best practice in primary care pathology: review 7.

    Journal of clinical pathology·2006
    Same author

    Cerebrospinal fluid findings in central neurocytoma.

    Cytopathology : official journal of the British Society for Clinical Cytology·2006
    Same author

    Best practice in primary care pathology: review 3.

    Journal of clinical pathology·2006

    Raised elastase (ELP)-alpha 1 antitrypsin complex levels are common in acute leukaemia and correlate with higher white cell counts. These levels normalize upon remission, suggesting ELP-alpha 1 antitrypsin complex as a potential biomarker.

    Area of Science:

    • Hematology
    • Biochemistry

    Background:

    • Acute leukaemia is characterized by uncontrolled proliferation of blast cells.
    • Elastase (ELP) and its complex with alpha 1 antitrypsin are implicated in inflammatory processes.
    • Factor XIII subunits (A and S) play a role in clot stabilization.

    Purpose of the Study:

    • To assess the incidence and significance of raised elastase (ELP)-alpha 1 antitrypsin complex levels in acute leukaemia patients.
    • To evaluate the reliability of low factor XIII subunit levels as an indicator of in vivo ELP release.
    • To correlate ELP-alpha 1 antitrypsin complex levels with disease parameters and remission status.

    Main Methods:

    • Studied 30 consecutive acute leukaemia patients before treatment.
    • Measured elastase (ELP)-alpha 1 antitrypsin complex levels.

    Related Experiment Videos

  • Assessed factor XIII subunits A and S levels.
  • Analyzed routine coagulation tests, white cell counts, and blast cell counts.

    • Main Results:

    • 15 out of 30 patients showed elevated ELP-alpha 1 antitrypsin complex levels.
    • Only 4 patients with raised complex levels had reduced factor XIII subunits.
    • Elevated ELP-alpha 1 antitrypsin complex levels correlated with higher white cell and blast cell counts.
    • Levels normalized in patients achieving remission.

    Conclusions:

    • Raised elastase (ELP)-alpha 1 antitrypsin complex levels are frequent in acute leukaemia.
    • Low factor XIII subunit levels are not a reliable indicator of in vivo ELP release in this context.
    • ELP-alpha 1 antitrypsin complex levels may serve as a biomarker for disease activity in acute leukaemia.