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Pregnancy and childbirth in patients with Glanzmann Thrombasthenia
Amihai Rottenstreich1,2,3,4, Barry S Coller1
1Laboratory of Blood and Vascular Biology, Rockefeller University, New York City, New York, USA.
Abstract:
Glanzmann thrombasthenia (GT) is a rare inherited platelet bleeding disorder caused by a quantitative and/or qualitative defect of the αIIbβ3 integrin. Pregnancy and delivery pose special challenges as they entail increased risks of both maternal and foetal bleeding that may be life-threatening. Multidisciplinary management throughout the preconception, intrapartum and peripartum periods is vital to optimize pregnancy outcomes. This Nutshell review focuses on the challenging management of pregnancy and childbirth in patients with GT.
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