Related Experiment Video
Updated: Jun 26, 2025
11:12
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
394
Hormesis as an adaptive response to infection.
Michael Bauer1, Maria Ermolaeva2, Mervyn Singer3
1Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany.
Trends in Molecular Medicine
|May 14, 2024
Summary
Low-level stress, known as hormesis, can enhance fitness. This study explores hormetic responses in host-pathogen interactions, proposing therapeutic uses for infectious diseases by targeting mitochondrial function.
Area of Science:
- Cellular biology
- Immunology
- Mitochondrial research
Background:
- Hormesis describes how low-level stress improves organismal fitness.
- Hormesis is linked to symbiotic interactions but unexplored in host-pathogen dynamics.
- Infection models show hormetic responses involving host mitochondrial function.
Purpose of the Study:
- To explore the role of hormesis in host-pathogen interactions.
- To investigate the potential therapeutic applications of mitohormesis in infectious diseases.
Main Methods:
- Review of existing literature on hormesis and infection.
- Analysis of studies reporting hormetic responses in experimental infection models.
- Focus on host mitochondrial function regulation during infection.
Main Results:
- Hormetic responses are observed in experimental models of infection.
- Regulation of host mitochondrial function is a common feature of these responses.
- Potential for therapeutic intervention through mitohormesis is suggested.
Conclusions:
- Mitohormetic responses may play a role in host-pathogen interactions.
- Harnessing mitohormesis offers a potential therapeutic strategy for infectious diseases.
- Further research is needed to validate and develop these therapeutic approaches.
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