Assessment of Selected Parameters of Heart Donors and Recipients and Their Impact on the Transplantation Result

Area of Science:

• Cardiology
• Transplantation Medicine
• Surgical Outcomes Research

Background:

• Orthotopic heart transplantation (OHT) is a life-saving procedure for end-stage heart failure.
• Optimizing OHT outcomes requires understanding the interplay of donor and recipient factors.

Purpose of the Study:

• To investigate the influence of donor and recipient characteristics on the success of orthotopic heart transplantation (OHT).

Main Methods:

• Analysis of 215 patients undergoing OHT between 2020 and 2023.
• Evaluation of donor demographics, medical history, and intraoperative parameters.
• Assessment of recipient outcomes, including mortality, need for mechanical support (IABP, ECMO), and dialysis.

Main Results:

• One-year mortality after OHT was 19.1%.
• Key predictors of mortality included longer aortic cross-clamping time, increased need for postoperative mechanical ventilation, dialysis, intra-aortic balloon pump (IABP), or extracorporeal membrane oxygenation (ECMO).
• Older recipient age and lower donor Empressin dosage were also associated with increased mortality.

Conclusions:

• Recipient age and postoperative support requirements are critical factors affecting OHT outcomes.
• While most donor factors showed no significant impact, Empressin dosage warrants further investigation.
• Identifying and mitigating these risk factors can potentially improve patient survival and recovery after OHT.