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The emerging understanding of Frizzled receptors

Shaoqin Zheng1, Ren Sheng1

  • 1College of Life and Health Science, Northeastern University, Shenyang, China.

FEBS Letters
|May 14, 2024
PubMed

Insights

The Frizzled receptor (FZD) family is crucial for Wnt signaling, impacting development and health. This review covers FZD structure, function, and targeted therapies for diseases like cancer.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • The Wnt signaling pathway regulates crucial physiological processes, including development and homeostasis.
  • Dysregulation of Wnt signaling is implicated in numerous human diseases, particularly cancers.
  • Frizzled receptors (FZDs) are key mediators of Wnt signaling, with 10 subtypes identified.

Purpose of the Study:

  • To review the latest research on Frizzled receptor (FZD) structure, function, and regulation.
  • To summarize advancements in targeted FZD therapies for human diseases.
  • To provide a foundation for future research directions in the FZD field.

Main Methods:

  • Literature review of recent studies on FZD receptors.
  • Analysis of FZD structure-function relationships.
  • Synthesis of data on FZD dysregulation in disease and therapeutic strategies.

Main Results:

  • FZD receptors, comprising 10 subtypes, play diverse roles in physiological processes.
  • Dysregulation of FZDs is linked to various diseases, especially human cancers.
  • Significant progress has been made in understanding FZD molecular mechanisms and developing targeted therapies.

Conclusions:

  • FZDs are critical components of the Wnt pathway with significant implications in disease.
  • Targeted therapies focusing on FZDs hold promise for treating various human conditions, particularly cancer.
  • Continued research into FZD structure, function, and regulation is essential for advancing therapeutic strategies.
Keywords:
Wnt signalingfrizzled receptortargeted therapy

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