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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Jun 26, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
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Approach to the Atypical Wound.

Sarah L Becker1, Shannon Kody1, Nicole M Fett1

  • 1Department of Dermatology, Oregon Health & Science University, 3303 S Bond Ave Building 1, 16th Floor, Portland, OR, 97239, USA.

American Journal of Clinical Dermatology
|May 14, 2024
PubMed
Summary

Managing atypical wounds requires prompt diagnosis and treatment, focusing on underlying causes and patient engagement for successful healing. Further research and training are essential to address the growing global prevalence of these complex dermatological conditions.

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Area of Science:

  • Dermatology
  • Wound Healing
  • Clinical Medicine

Background:

  • Atypical wounds present significant diagnostic and therapeutic challenges.
  • The global prevalence of atypical wounds is increasing, necessitating specialized management skills.
  • Understanding the underlying etiology is paramount for effective treatment of atypical wounds.

Purpose of the Study:

  • To highlight the importance of prompt and accurate management of atypical wounds.
  • To emphasize an integrated approach for successful wound closure.
  • To underscore the need for advances in treatment, research, and clinical training.

Main Methods:

  • Literature review on atypical wound management.
  • Analysis of diagnostic and therapeutic challenges.
  • Synthesis of integrated care approaches.

Main Results:

  • Atypical wound heterogeneity complicates diagnosis and treatment.
  • Addressing the root cause is critical for successful outcomes.
  • An integrated approach including pain management and patient engagement promotes healing.

Conclusions:

  • Prompt and accurate management of atypical wounds is an essential skill for dermatologists.
  • Further research and clinical training are vital to combat the rising burden of atypical wounds.
  • Advances in treatment are necessary to improve patient outcomes.