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Serum levels of lipoprotein-associated phospholipase A2 are associated with coronary atherosclerotic plaque

Shudong Zhang¹, Jiangang Wang², Shuai Chen^3,4

¹Department of Cardiovascular Medicine, Wuxi branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, China.

BMC Cardiovascular Disorders

|May 14, 2024

Summary

Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are linked to coronary plaque progression in type 2 diabetes mellitus (T2DM) and non-diabetic individuals. Higher Lp-PLA2 levels indicate increased cardiovascular risk, particularly in diabetic patients.

Keywords:

Lp-PLA2 Plaque progression Type 2 diabetes mellitus

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Published on: September 26, 2018

Area of Science:

Cardiovascular Medicine
Diabetology
Biomarker Research

Background:

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a pro-inflammatory mediator implicated in cardiovascular diseases.
Its role is particularly concerning in diabetes mellitus, where it contributes to poor outcomes.

Purpose of the Study:

To investigate the association between serum Lp-PLA2 levels and coronary plaque progression.
To compare this association in patients with type 2 diabetes mellitus (T2DM) versus non-diabetic individuals.

Main Methods:

Quantitative coronary angiography was performed at baseline and after one year.
Serum Lp-PLA2 levels were measured in T2DM patients (with and without plaque progression) and non-diabetic patients (with and without plaque progression).

Main Results:

Elevated serum Lp-PLA2 levels correlated significantly with coronary plaque progression in both diabetic and non-diabetic groups.
The association was stronger in diabetic patients, with Lp-PLA2 identified as an independent determinant of plaque progression.

Conclusions:

Serum Lp-PLA2 levels are significantly associated with coronary atherosclerotic plaque progression.
This association is more pronounced in patients with type 2 diabetes mellitus.