Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GATA6 marks fibrosis-associated stromal cells rather than repair macrophages in kidney disease.

Scientific reports·2026
Same author

Beyond binary: rethinking subphenotyping in ARDS as a continuous spectrum.

Intensive care medicine·2026
Same author

Reply to Siddiqui et al., Godbout et al., and to Chang and Mao.

American journal of respiratory and critical care medicine·2026
Same author

New and persistent psychoactive medication use in intensive care unit survivors with COVID-19: a multicentre population-based cohort study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.

Stem cells translational medicine·2026
Same author

Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice.

Science (New York, N.Y.)·2026

Related Experiment Video

Updated: Jun 26, 2025

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.0K

Endotyping in ARDS: one step forward in precision medicine.

Andréanne Côté1,2, Chel Hee Lee2,3, Sayed M Metwaly4,5

  • 1Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Quebec-Université Laval, Quebec, Canada.

European Journal of Medical Research
|May 14, 2024
PubMed
Summary

Researchers identified three distinct subgroups of acute respiratory distress syndrome (ARDS) patients using clinical data and biomarkers. These ARDS patient groups show varying mortality rates, aiding personalized treatment strategies.

Keywords:
Acute respiratory distress syndromeCluster analysisFeature selectionMixed data analysis

More Related Videos

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.6K
Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

17.0K

Related Experiment Videos

Last Updated: Jun 26, 2025

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.0K
Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.6K
Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

17.0K

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Biomarker Discovery

Background:

  • The Berlin definition of ARDS relies solely on clinical criteria.
  • Understanding ARDS pathobiology is crucial for personalized treatment approaches.
  • This study aimed to define ARDS phenotypes/endotypes using clinical and pathophysiological data.

Purpose of the Study:

  • To define and describe ARDS phenotypes/endotypes by integrating clinical and pathophysiological parameters.
  • To identify distinct ARDS subgroups within a Canadian cohort.
  • To explore the impact of these subgroups on patient mortality.

Main Methods:

  • A cohort of adult ARDS patients from Calgary, Canada, was analyzed.
  • Plasma cytokine levels and clinical parameters were measured within 24 hours of ICU admission.
  • A latent class model (LCM) was employed to identify ARDS subgroups and differentiating features.

Main Results:

  • The LCM identified three distinct ARDS subgroups (n=64, n=86, n=30) based on 23 differentiating features.
  • Key discriminating features included IL-8, IL-6, IL-10, TNF-a, and serum lactate.
  • Mortality rates varied significantly across the identified subgroups, with IL-8 and APACHE II strongly predicting mortality.

Conclusions:

  • Subgrouping ARDS patients using biomarkers and clinical data effectively categorizes this heterogeneous condition.
  • The study identified three ARDS subgroups with differing mortality levels.
  • This model holds potential for improving clinical trial design, prognostication, and treatment selection in ARDS.