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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

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Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tobacco Smoking Is Associated With Cutaneous Squamous Cell Carcinoma But Not With Basal Cell Carcinoma Or Melanoma In Adult Subjects At Risk Of Skin Cancer: A Cross-sectional Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tobacco Smoking Is Associated With Cutaneous Squamous Cell Carcinoma But Not With Basal Cell Carcinoma Or Melanoma In Adult Subjects At Risk Of Skin Cancer: A Cross-sectional Study.

Related Experiment Video

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

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Tobacco smoking is associated with cutaneous squamous cell carcinoma but not with basal cell carcinoma or melanoma in adult subjects at risk of skin cancer: A cross-sectional study.

Ilmari Uotila1, Hanna Siiskonen1, Salla Haimakainen1

  • 1Department of Dermatology, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.

Tobacco Induced Diseases
|May 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
basal cell carcinomamelanomaskin cancersquamous cell carcinoma

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Smoking is linked to a higher risk of squamous cell carcinoma (SCC), but not other skin cancers like melanoma or basal cell carcinoma. The study found no significant association between smoking and skin aging or nevi.

Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • The link between tobacco smoking and skin conditions like photodamage, precancerous lesions, and skin cancers remains incompletely understood.
  • Ultraviolet radiation and immunosuppression are known factors influencing skin carcinogenesis, alongside smoking.
  • Investigating smoking's role is crucial for understanding skin cancer development in at-risk populations.

Purpose of the Study:

  • To examine the association between smoking and cutaneous photoaging, actinic keratosis (AK), various skin cancers, and nevi.
  • To assess these associations in adult subjects with a predisposition to skin cancer.
  • To differentiate the impact of smoking from other factors like age and immunosuppression.

Main Methods:

  • A cross-sectional study involving 488 adult subjects (aged 21-79) at Kuopio University Hospital, Finland.
tobacco smoking
  • Data collection included skin lesion assessment, photoaging severity, nevi count, and tobacco pack-years (TPY).
  • Statistical analyses, including logistic regression, were used to evaluate associations while controlling for confounding factors like age and immunosuppression.

    • Main Results:

    • No significant association was found between tobacco pack-years (TPY) and overall skin photoaging, facial photoaging, actinic keratosis (AK), or nevi after adjusting for confounders.
    • TPY did not show a significant association with melanoma, basal cell carcinoma, or any skin cancer type.
    • Ever-smokers had a higher crude odds ratio for squamous cell carcinoma (SCC). Notably, a TPY of ≤10 was associated with an increased multivariable adjusted odds ratio for SCC, whereas TPY >10 was not.

    Conclusions:

    • Smoking is associated with an increased risk of developing squamous cell carcinoma (SCC), but this association is not dose-dependent.
    • The study found no significant link between smoking and basal cell carcinoma or melanoma.
    • The impact of smoking on cutaneous photoaging, AK, and nevi appears to be minimal in this study population.