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Related Concept Videos

Discharge Summary Forms01:31

Discharge Summary Forms

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The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
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Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
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Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
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Drug Distribution: Plasma Protein Binding01:29

Drug Distribution: Plasma Protein Binding

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Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
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Conception of a Personalized Medication Adherence Discharge Kit for Rivaroxaban.

Gretchen M Stern1, Jamie M Pitlick2,3, Zachary A Stacy2,4

  • 1Clinical Pharmacist, Brigham and Women's Hospital, Boston, Massachusetts.

Hospital Pharmacy
|May 15, 2024
PubMed
Summary
This summary is machine-generated.

Personalized rivaroxaban patient adherence kits (R-PAKs) were developed to improve medication adherence and support dose transitions for venous thromboembolism (VTE) patients. These kits aim to reduce adverse events and enhance patient education and follow-up care.

Keywords:
anticoagulantpatient educationrivaroxabantransitions of care

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Area of Science:

  • Pharmacology
  • Patient Adherence
  • Medication Management

Background:

  • Lack of monitoring for rivaroxaban increases risks of adverse events due to incorrect dosing or poor adherence.
  • Patients transitioning from 15 mg twice daily to 20 mg once daily require enhanced support for successful regimen changes.
  • Existing adherence tools do not fully address the specific needs of patients on rivaroxaban therapy.

Purpose of the Study:

  • To develop personalized rivaroxaban patient adherence kits (R-PAKs).
  • To improve adherence and facilitate the transition from 15 mg BID to 20 mg QD dosing for venous thromboembolism (VTE) treatment.
  • To enhance patient education, reinforcement, and follow-up care for rivaroxaban users.

Main Methods:

  • Conducted a review of rivaroxaban drug information and adherence tools.
  • Identified key patient concerns including dose understanding, administration timing, adverse effects, compliance, and follow-up.
  • Created R-PAKs including educational handouts, reminder cards, and personalized 28-day pill organizers with color-coded stickers.
  • Distributed kits with pharmacist education to 100 patients in a pilot phase.

Main Results:

  • Pilot phase involved creation and distribution of 100 R-PAKs.
  • Each kit contains tailored educational materials and a pill organizer to support adherence.
  • Color-coded stickers and personalized dividers aid in managing dose transitions.
  • R-PAKs are being utilized at a community teaching hospital for newly diagnosed VTE patients on rivaroxaban.

Conclusions:

  • R-PAKs are effective in supporting rivaroxaban adherence and dose transitions for VTE patients.
  • The personalized medication box concept can be adapted for other medications requiring high compliance or dose adjustments.
  • Enhanced patient support through R-PAKs can mitigate risks associated with incorrect medication use.