Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Therapy01:28

Drug Therapy

42
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
42
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

126
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
126
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

252
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
252
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

354
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
354
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

123
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
123
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

60
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
60

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative characterization of two scorpion toxins, BlTx1 and BlTx2, identifies BlTx2 as a Kv4.1-selective peptide.

Peptides·2026
Same author

Editorial: Optimizing medication management in older adults: addressing polypharmacy, deprescribing and represcribing challenges.

Frontiers in medicine·2026
Same author

Increasing Medical Students Clinical Training Capacity Through the Establishment of Dedicated, Academic Out-patients' Clinics. The Case of NAC-Neurology Academic Clinic in a Tertiary Medical Center.

Journal of medical education and curricular development·2025
Same author

Cross-Cultural Adaptation and Clinical Validation of TIME Criteria to Detect Potentially Inappropriate Medication Use in Older Adults: Methodological Report from the TIME International Study Group.

Drugs & aging·2024
Same author

Admission characteristics of patients with short term hospitalization.

Israel journal of health policy research·2024
Same author

Timing of Lung Transplant Referral in Patients with Severe COVID-19 Lung Injury Supported by ECMO.

Journal of clinical medicine·2023

Related Experiment Video

Updated: Jun 26, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

Optimizing clinical outcomes in polypharmacy through poly-de-prescribing: a longitudinal study.

Doron Garfinkel1, Yuval Levy2

  • 1Center for Appropriate Medication Use, Sheba Medical Center, Ramat Gan, Israel.

Frontiers in Medicine
|May 15, 2024
PubMed
Summary

Reducing the number of medications for older adults (polypharmacy) improved their quality of life and cognitive function. The more drugs de-prescribed, the greater the improvement in patient outcomes.

Keywords:
dementiafrailtygeriatric palliative approachinappropriate medication usemulti-morbiditypoly-de-prescribingpolypharmacy

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K

Related Experiment Videos

Last Updated: Jun 26, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K

Area of Science:

  • Gerontology
  • Clinical Pharmacy
  • Public Health

Background:

  • Polypharmacy is prevalent in older adults, increasing the risk of adverse drug events and reduced quality of life.
  • Systematic medication review and de-prescribing are crucial for optimizing healthcare in the elderly population.

Purpose of the Study:

  • To evaluate the impact of poly-de-prescription (PDP) on quality of life (QoL) and clinical outcomes in older adults.
  • To determine if the extent of medication de-prescribing correlates with improvements in QoL and clinical outcomes.

Main Methods:

  • A prospective longitudinal cohort study involving 307 community-dwelling older adults (aged 65+) on at least six prescription drugs.
  • Poly-de-prescription recommendations were made using the Garfinkel algorithm, with participants followed for 3-10 years.
  • Participants were divided into two groups: those who discontinued >50% of drugs (PDP group) and those who discontinued <50% (non-responders, NR).

Main Results:

  • The PDP group de-prescribed significantly more medications (6.7) compared to the NR group (2.2).
  • No significant differences were observed in 3-year survival rates or hospitalizations between the groups.
  • The PDP group showed significant improvements in functional status, cognitive function, and overall satisfaction with the intervention.

Conclusions:

  • Poly-de-prescribing in older adults yields significant benefits in clinical outcomes and QoL without negatively impacting survival or hospitalization rates.
  • The degree of improvement in patient outcomes directly correlates with the extent of medication de-prescribing.
  • Widespread application of de-prescribing strategies, like the Garfinkel algorithm, could lead to substantial improvements in QoL for millions, representing a win-win for patients and healthcare economics.