Medullary Thyroid Cancer: Epidemiology and Characteristics According to Data From the Marne-Ardennes Register 1975-2018
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View abstract on PubMed
Summary
This summary is machine-generated.Medullary thyroid cancer (MTC) incidence shows a moderate increase over 40 years. Sporadic MTC has a worse prognosis than hereditary MTC, highlighting the need for continued research and patient monitoring.
Area Of Science
- Epidemiology
- Oncology
- Endocrinology
Background
- Medullary thyroid cancer (MTC) is a rare but significant endocrine malignancy.
- Understanding MTC incidence trends and prognostic factors is crucial for public health and clinical management.
Purpose Of The Study
- To analyze the incidence evolution of Medullary thyroid cancer (MTC) over a 40-year period.
- To perform descriptive and survival analyses, comparing hereditary and sporadic MTC forms.
Main Methods
- Retrospective epidemiological study utilizing data from the Marne-Ardennes registry (1975-2018).
- Inclusion of 260 MTC patients with standardized incidence calculation and Kaplan-Meier survival analysis.
Main Results
- Standardized MTC incidence increased from 0.41 to 0.57/100,000 person-years between 1986-1996 and 2008-2018.
- Hereditary MTC accounted for 21.2% of cases; sporadic MTC demonstrated a poorer prognosis compared to hereditary forms.
- The 5-year survival rate was 88.4%, with 58.5% of patients achieving complete remission.
Conclusions
- A moderate increase in Medullary thyroid cancer incidence was observed between 1975 and 2018.
- Prognosis for sporadic MTC remains significantly worse than for hereditary MTC.
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