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Related Experiment Video

Updated: Jun 26, 2025

Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

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Diabetes mellitus, systemic inflammation and overactive bladder.

Qingliu He1,2, Lizhen Wu3, Changqi Deng2

  • 1Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Frontiers in Endocrinology
|May 15, 2024
PubMed
Summary

Diabetes significantly increases overactive bladder (OAB) risk. Systemic inflammation, particularly white blood cells and neutrophils, mediates this link, with glycohemoglobin being a key indicator.

Keywords:
NHANESdiabetesepidemiologyinflammationoveractive bladder

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Area of Science:

  • Urology
  • Endocrinology
  • Epidemiology

Background:

  • Growing evidence suggests a link between diabetes and overactive bladder (OAB).
  • Large-scale epidemiological data on this association remain limited.

Purpose of the Study:

  • To investigate the association between diabetes mellitus, diabetes-related markers, and inflammatory biomarkers with OAB.
  • To explore the mediating role of inflammation in the diabetes-OAB relationship.
  • To identify key predictors of OAB in diabetic populations using machine learning.

Main Methods:

  • Cross-sectional analysis of 23,863 participants from NHANES surveys.
  • Logistic regression and restricted cubic splines to assess associations.
  • Mediation analysis and XGBoost machine learning models were employed.

Main Results:

  • OAB prevalence was 77% higher in participants with diabetes mellitus.
  • Diabetes-related markers showed a monotonic increase in OAB odds.
  • White blood cells and neutrophils significantly mediated the association between diabetes markers and OAB.
  • Glycohemoglobin was identified as the most important indicator for OAB via XGBoost.

Conclusions:

  • Diabetes mellitus and related markers are strongly associated with OAB.
  • Systemic inflammation acts as a crucial mediator in the diabetes-OAB relationship.
  • Glycohemoglobin and inflammatory markers are key factors in OAB development among diabetic patients.