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Adaptive bootstrap tests for composite null hypotheses in the mediation pathway analysis.

Yinqiu He1, Peter X K Song2, Gongjun Xu3

  • 1Department of Statistics, University of Wisconsin, Madison, WI, USA.

Journal of the Royal Statistical Society. Series B, Statistical Methodology
|May 15, 2024
PubMed
Summary
This summary is machine-generated.

We developed a new adaptive bootstrap framework to improve mediation analysis. This method enhances statistical power for testing mediation effects (ME) by addressing challenges posed by composite null hypotheses.

Keywords:
bootstrapcomposite hypothesismediation analysisstructural equation model

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Area of Science:

  • Statistics
  • Biostatistics
  • Epidemiology

Background:

  • Mediation analysis investigates how exposures influence outcomes via intermediate variables.
  • Current mediation effect (ME) testing faces challenges due to composite null hypotheses, leading to conservative and underpowered tests.
  • There is a growing need for robust mediation analysis across scientific disciplines.

Purpose of the Study:

  • To develop an adaptive bootstrap testing framework for mediation pathway analysis.
  • To enhance statistical power and provide type I error control under composite null hypotheses.
  • To address limitations of existing methods in mediation effect testing.

Main Methods:

  • An adaptive bootstrap testing framework was developed.
  • The framework accommodates various composite null hypotheses in mediation analysis.
  • Applied to product of coefficients and joint significance tests.

Main Results:

  • The proposed adaptive testing procedures offer improved type I error control.
  • The methodology significantly enhances statistical power compared to existing mediation tests.
  • Theoretical properties and numerical examples demonstrate the framework's effectiveness.

Conclusions:

  • The adaptive bootstrap framework offers a powerful solution for mediation analysis.
  • This approach improves the reliability and power of testing mediation effects.
  • The methodology is broadly applicable to various mediation pathway analyses.