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Updated: Jun 26, 2025

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Molecular and Functional Profiling of Gαi as an Intracellular pH Sensor

Ajit Prakash1, Zijian Li1, Venkata R Chirasani1

  • 1Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Research Square
|May 15, 2024
PubMed
Summary

Intracellular pH changes alter the structure and stability of Gαi proteins, impacting G-protein-coupled receptor (GPCR) signaling. This study reveals a pH-sensing network in Gαi, offering new therapeutic targets for diseases involving GPCR pathways.

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