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Persistent Lactatemia in Mauriac Syndrome.
1University of Calgary, Calgary, Alberta, Canada.
Case Reports in Endocrinology
|May 15, 2024
Summary
Mauriac syndrome, a rare complication of type 1 diabetes mellitus (T1DM), involves liver issues and persistent high lactate during diabetic ketoacidosis (DKA). Optimal blood glucose control is key for reversing liver changes.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Pediatric Endocrinology
Background:
- Mauriac syndrome is a rare complication in type 1 diabetes mellitus (T1DM) patients with poorly controlled hyperglycemia.
- It is characterized by hepatomegaly, growth delay, and cushingoid features, alongside persistent lactatemia during diabetic ketoacidosis (DKA) management.
Observation:
- A case report details an 18-year-old T1DM patient presenting with DKA, who subsequently developed elevated lactate levels.
- This clinical presentation led to the diagnosis of Mauriac syndrome.
Findings:
- Persistent lactatemia in Mauriac syndrome is not fully understood but is suspected to stem from glycogenic hepatopathy.
- This condition involves liver enlargement, altered glucose metabolism, and inappropriate lactate production.
Implications:
- The liver abnormalities associated with Mauriac syndrome are reversible with improved glycemic control.
- Intensive medical and psychosocial support is crucial for T1DM patients to achieve better blood glucose management and mitigate syndrome progression.
