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Clinicopathological characteristics and tumor infiltrating immune cells associations of PD-L1 tumor expression in non-small cell lung cancer patients

  • 0Laboratory of cellular and molecular pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.
La Tunisie Médicale +

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May 15, 2024

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May 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study found a significant link between PD-L1 expression and smoking status in Moroccan non-small cell lung carcinoma (NSCLC) patients. However, PD-L1 expression was not significantly associated with tumor-infiltrating immune cells.

Area Of Science

  • Oncology
  • Immunology
  • Pathology

Background

  • Non-small cell lung carcinoma (NSCLC) is a major global health concern.
  • Programmed death-ligand 1 (PD-L1) expression is a key biomarker in NSCLC, influencing immunotherapy response.
  • Understanding factors affecting PD-L1 expression is crucial for personalized treatment strategies.

Purpose Of The Study

  • To investigate the relationship between PD-L1 tumor expression, clinicopathological features, and tumor-infiltrating immune cells (ICs) in Moroccan NSCLC patients.
  • To analyze PD-L1 expression patterns based on histological type, smoking status, and stage.
  • To explore the coexpression of PD-L1 on tumor cells and ICs.

Main Methods

  • Retrospective analysis of 316 NSCLC patient samples from Casablanca, Morocco (2019-2021).
  • Immunohistochemistry (IHC) using the 22C3 clone to evaluate PD-L1 expression on tumor cells (TCs) and ICs.
  • Categorization of PD-L1 tumor proportion score (TPS) into negative (<1%), low (1-49%), and high (≥50%) expression levels.

Main Results

  • 56.6% of samples showed negative PD-L1 expression, 16.8% low, and 26.6% high expression.
  • A significant association was found between high PD-L1 expression (TPS ≥50%) and smoking status (P=0.019).
  • No significant association was observed between PD-L1 expression and the presence or IHC expression of PD-L1 on infiltrating ICs (P=0.652, P=0.259).

Conclusions

  • PD-L1 expression in NSCLC is significantly associated with smoking status in the Moroccan population.
  • The presence and PD-L1 expression of tumor-infiltrating immune cells do not show a significant association with overall PD-L1 tumor expression.
  • Further research into factors influencing PD-L1 expression in NSCLC is warranted.

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