Recent Developments On Activatable Turn-On Fluorogenic Donors of Hydrogen Sulfide (H₂S)

Area of Science:

• Biochemistry
• Pharmacology
• Chemical Biology

Background:

• Hydrogen sulfide (H₂S) is the third gasotransmitter, crucial for cellular homeostasis.
• Dysregulation of endogenous H₂S contributes to various disease states.
• Exogenous H₂S donors can restore cellular H₂S levels and homeostasis.

Purpose of the Study:

• To review recent advancements in stimuli-responsive, turn-on fluorogenic H₂S donors.
• To explore the potential biological and pharmaceutical applications of these novel H₂S donors.

Main Methods:

• Development of small-molecule non-fluorogenic organosulfur compounds as H₂S donors.
• Recent development of stimuli-responsive turn-on fluorogenic H₂S donors.
• Utilizing simultaneous turn-on fluorogenic processes for real-time H₂S monitoring.

Main Results:

• Numerous non-fluorogenic H₂S donors have been developed and investigated.
• Emerging fluorogenic H₂S donors offer advantages for non-invasive H₂S monitoring.
• These donors show promise for various pharmaceutical applications.

Conclusions:

• Fluorogenic H₂S donors represent a significant advancement in H₂S research.
• They enable real-time monitoring of H₂S release, aiding therapeutic development.
• Further research into their biological applications is warranted.