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Updated: Jun 26, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Synthesis and characterization of Pt(II) and Au(I) complexes with N-oxy-heterocyclic carbene ligands (NOHCs)
Alice Benin1,2, Joshua Immanuel Kollar2, Tim Riesebeck2
1Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, 35131, Padova, Italy. cristina.tubaro@unipd.it.
Abstract:
Two N-alkyloxy-N'-phenylimidazolium proligands and the corresponding platinum(II) cyclometalated N-alkyloxyimidazol-2-ylidene complexes with β-diketonate auxiliary ligands, [(CNOHC^C*)Pt(L∩L)] (L∩L = acetyacetonate (acac) or 1,3-bis(2,4,6-trimethylphenyl)-propane-1,3-dionato (mesacac)) were synthesized and fully characterized. In addition, a Au(I) monocarbene complex was synthesized, isolated and characterized. Solid-state structures of two cyclometalated platinum(II) NOHC complexes and the Au(I) NOHC complex were obtained providing structural proof.
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