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Published on: December 17, 2011

Polyclonal B-cell activation of rabbit Peyer's patch

D A Axelrod

    Clinical Immunology and Immunopathology
    |September 1, 1985
    PubMed

    This study delineates the culture conditions and cellular requirements for pokeweed mitogen (PWM)-induced polyclonal B-lymphocyte activation of rabbit Peyer's patch cells for immunoglobulin secretion. This system was optimal with a cell density of 3 X 10(5) cells/ml and a culture duration of 7 days, in round-bottom containers. Although glass-plate-adherent cells did not appear to influence this process, the immunoglobulin responses to PWM were T cell dependent. This study supplies a foundation for further work on the mechanisms of polyclonal activation of B cells in the rabbit Peyer's patch.

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