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Association of biological age acceleration with cardiac morphology, function, and incident heart failure: insights
Rui Mao1,2,3, Fan Wang1,2,3, Yun Zhong1,2,3
1Department of Dermatology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha City, Hunan Province 410008, China.
European Heart Journal. Cardiovascular Imaging
|May 15, 2024
Summary
Accelerated biological aging is linked to poorer heart structure and function. This biological age acceleration increases heart failure risk in adults, suggesting it as a key risk indicator.
Area of Science:
- Cardiology
- Gerontology
- Biomarkers
Background:
- Advanced age increases cardiovascular event risk.
- The link between biological age acceleration (BAA), cardiac metrics, and heart failure (HF) needs clarification.
Purpose of the Study:
- To investigate the association between BAA and cardiac structure/function.
- To determine if BAA predicts heart failure risk.
Main Methods:
- Utilized UK Biobank data with Klemera-Doubal and PhenoAge methods for BAA assessment.
- Employed cardiovascular magnetic resonance (CMR) imaging for cardiac phenotyping.
- Applied regression and Mendelian randomization analyses for causality.
Main Results:
- Increased BAA correlated with adverse cardiac changes (reduced ventricular mass, volume, stroke volumes).
- Higher BAA significantly elevated heart failure risk over 13.8 years (26-33% per SD increase).
- Mendelian randomization suggested a causal relationship between BAA, cardiac metrics, and HF.
Conclusions:
- Accelerated biological aging is a potential risk indicator for cardiac alterations and heart failure onset.
- BAA may guide risk assessment and intervention strategies in middle-aged and older adults.
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