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Updated: Jun 26, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Short term creatine loading improves strength endurance even without changing maximal strength, RPE, fatigue index,
Edilson Tadeu F Furtado1, João Paulo L DE Oliveira1, Isabela S B Pereira1
1Universidade Federal de Lavras, Departamento de Nutrição, Faculdade de Ciências da Saúde, Trevo Rotatório Professor Edmir Sá Santos, s/n, 37203-202 Lavras, MG, Brazil.
Creatine supplementation for five days enhanced strength endurance by increasing repetitions and total work in trained men. However, it did not significantly improve maximal strength.
Area of Science:
- Sports Science
- Exercise Physiology
- Nutritional Biochemistry
Background:
- Creatine is a popular supplement among athletes aiming to boost strength and muscle mass.
- Understanding creatine's specific effects on different aspects of strength performance is crucial for optimizing training protocols.
Purpose of the Study:
- To investigate the impact of a five-day creatine supplementation regimen on maximal strength and strength endurance in trained men.
- To assess secondary physiological and perceptual responses, including blood lactate, rate of perceived effort, fatigue index, and mood state.
Main Methods:
- A double-blind, placebo-controlled, randomized crossover study involving twelve strength-trained men.
- Participants underwent a five-day supplementation period with either creatine (20g creatine + 10g maltodextrin) or a placebo (20g starch + 10g maltodextrin).
- Measurements included maximal strength (1RM bench press), strength endurance (sets to failure at 70% 1RM), blood lactate, RPE, fatigue index, and mood state, assessed pre- and post-supplementation.
Main Results:
- Creatine supplementation significantly increased the number of repetitions performed to concentric failure (Δ = +3.4 reps, p = 0.036) and total work completed (Δ = +199.5 arbitrary units, p = 0.038) compared to placebo.
- No significant changes were observed in maximal strength, blood lactate levels, rate of perceived effort, fatigue index, or mood state in either the creatine or placebo group.
- The effect size for increased repetitions and total work in the creatine group was moderate (g = 0.53 and g = 0.52, respectively).
Conclusions:
- A five-day creatine loading phase can enhance muscular endurance, enabling individuals to perform more repetitions and generate greater total work during resistance exercise.
- Short-term creatine supplementation does not appear to significantly improve maximal strength or alter key physiological and perceptual fatigue markers in strength-trained individuals.
- These findings suggest that creatine's primary benefit within a short loading period may lie in improving the capacity for sustained muscular effort rather than peak force production.
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