Evaluation of some immunological markers in co-infection of COVID-19 with thrush candidiasis

Heam Qaid Mohammed Al-Kenani ¹, Orass Madhi Shaheed ¹

⁰University of Al-Qadisiyah, College of Medicine, Department of Medical Microbiology - Diwaniya, Iraq.

Revista Da Associacao Medica Brasileira (1992) +

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May 15, 2024

View abstract on PubMed

Summary

This study investigated the immune response in patients with COVID-19 and concurrent Thrush Candida albicans infections. Findings reveal distinct immune cell proportions and altered interleukin levels, highlighting the impact of co-infections on patient health.

Area Of Science

Immunology and infectious diseases.
Investigating the complex interplay between viral and fungal co-infections.

Background

COVID-19 presents significant health risks, with potential for secondary fungal infections like Thrush Candida albicans.
Understanding the immunological impact of these co-infections is crucial for patient management.

Purpose Of The Study

To assess the effect of concurrent COVID-19 and Thrush Candida albicans infection on patient health.
To measure immune cell proportions and key interleukin levels (IL-8, IL-10, IL-17, IL-33) in different patient groups.

Main Methods

Study included 70 patients (COVID-19, thrush candidiasis, Thrush Candida albicans) and 50 healthy controls.
COVID-19 diagnosed via RT-PCR; C. albicans identified by culture and biochemical tests.
Blood counts and interleukin levels determined using Ruby equipment and ELISA kits.

Main Results

Distinct immune cell profiles observed: neutrophils/basophils high in Thrush Candida albicans, lymphocytes/eosinophils in COVID-19, monocytes in thrush candidiasis.
Elevated IL-8 and IL-17 in Thrush Candida albicans patients; highest IL-33 in COVID-19 patients.
All patient groups showed decreased IL-10 compared to controls.

Conclusions

Patient groups exhibited increased neutrophils, lymphocytes, and monocytes.
A significant association was found between pro-inflammatory interleukins and specific immune cells.