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Correlation of HBV Core-Related Antigen with Conventional Serologic Indicators of Hepatitis B and Disease Stage

Yinmiao Wang, Xiaohua Jin, Qunxin Peng

    Clinical Laboratory
    |May 15, 2024
    PubMed

    Insights

    Hepatitis B core-related antigen (HBcrAg) is a reliable marker for diagnosing Hepatitis B virus (HBV) infection. It correlates with HBV DNA and HBeAg, aiding in identifying occult HBV infections.

    Area of Science:

    • Hepatology
    • Virology
    • Clinical Diagnostics

    Background:

    • Hepatitis B virus (HBV) infection poses a significant global health challenge.
    • Serological indicators are crucial for diagnosing hepatitis B.
    • HBV core-related antigen (HBcrAg) shows strong correlation with intrahepatic cccDNA, HBV DNA, and HBeAg.

    Purpose of the Study:

    • To explore the correlation between HBcrAg and conventional serological markers.
    • To assess HBcrAg's utility in hepatitis B diagnosis and staging.
    • To provide a reliable basis for hepatitis B management.

    Main Methods:

    • Collected 542 patient serum samples from November 2021 to March 2022.
    • Measured serum HBcrAg using magnetic particle chemiluminescence.
    • Analyzed HBcrAg alongside other conventional serum indicators.

    Main Results:

    • HBcrAg demonstrated a strong positive correlation with HBV DNA (r=0.655) and HBeAg (r=0.945).
    • Mean HBcrAg levels were highest in immune-tolerant and immune-clearance phases.
    • HBcrAg showed higher positivity rates even when HBV DNA and HBeAg were negative.

    Conclusions:

    • Serum HBcrAg is a dependable marker for hepatitis B diagnosis.
    • HBcrAg can help prevent underdiagnosis of occult HBV infection.
    • HBcrAg aids in understanding hepatitis B disease staging.
    Abstract

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