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  11. Aspartate Transaminase-to-albumin Ratio (atar), A Novel Prognostic Index, Predicts Outcomes In Patients With Small-cell Lung Cancer

Aspartate Transaminase-to-Albumin Ratio (ATAR), a Novel Prognostic Index, Predicts Outcomes in Patients with Small-Cell Lung Cancer

Shan Liu, Hanxiao Ren, Ruiling Zu

    Clinical Laboratory
    |May 15, 2024

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    View abstract on PubMed

    Summary
    This summary is machine-generated.

    The aspartate transaminase-to-albumin ratio (ATAR) can predict survival in small cell lung cancer (SCLC) patients. High ATAR levels indicate a higher risk of progression and poorer overall survival in SCLC.

    Area of Science:

    • Oncology
    • Medical Diagnostics
    • Prognostic Biomarkers

    Background:

    • Small cell lung cancer (SCLC) is aggressive with poor prognoses.
    • Identifying high-risk SCLC patients is crucial for improving survival.
    • The aspartate transaminase-to-albumin ratio (ATAR) was investigated as a prognostic factor.

    Purpose of the Study:

    • To evaluate the aspartate transaminase-to-albumin ratio (ATAR) as a prognostic factor for overall survival (OS) in SCLC patients.
    • To determine if ATAR can independently predict survival outcomes in SCLC.
    • To compare the prognostic value of ATAR with other established markers.

    Main Methods:

    • Retrospective analysis of 196 SCLC patients' medical and blood data.
    • Division of patients into high-risk (>0.54) and low-risk (≤0.54) ATAR groups using the Youden index.

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  • Prognostic factor analysis for OS using Kaplan-Meier, univariate/multivariate analyses, Cox regression, and C-index.

    • Main Results:

    • High-risk ATAR patients showed significantly lower OS (p < 0.0001).
    • Elevated ATAR is an independent adverse predictor of OS (p < 0.001, HR = 1.907).
    • ATAR outperformed ALB, PNI, and SII in predicting SCLC outcomes and improved prognostic models when combined.

    Conclusions:

    • Peripheral blood ATAR serves as an independent prognostic index for SCLC patients prior to treatment.
    • ATAR effectively stratifies survival across different stages of SCLC.
    • ATAR demonstrates superior prognostic value compared to ALB, PNI, and SII.