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Does an Aspirin a Day Take the MASLD Away?
Amedeo Lonardo1, Ming-Hua Zheng2,3,4,5
1Department of Internal Medicine, Ospedale Civile di Baggiovara (-2023), Azienda Ospedaliero-Universitaria di Modena, 41100, Modena, Italy. a.lonardo@libero.it.
Aspirin shows promise in treating metabolic dysfunction-associated steatotic liver disease (MASLD). Research suggests it may reduce liver fat and fibrosis, potentially preventing liver cancer.
Area of Science:
- Hepatology
- Pharmacology
- Gastroenterology
Background:
- Aspirin, a widely used medication, has diverse therapeutic applications.
- Recent research suggests potential benefits of aspirin in liver disease.
- Nonalcoholic fatty liver disease/metabolic dysfunction fatty liver disease/metabolic dysfunction-associated steatotic liver disease (NAFLD/MAFLD/MASLD) is a growing health concern.
Purpose of the Study:
- To review the current evidence on aspirin's efficacy in MASLD.
- To explore the mechanisms underlying aspirin's potential hepatoprotective effects.
- To discuss the implications of aspirin as a therapeutic agent for MASLD.
Main Methods:
- Summary and discussion of the latest randomized controlled trial on aspirin for non-cirrhotic MASLD.
- Review of existing epidemiological data on aspirin's hepatic effects.
- Examination of proposed mechanisms, including effects on adipose tissue, liver, and sex differences.
Main Results:
- Evidence suggests aspirin may possess antisteatotic and antifibrotic properties in the liver.
- Potential role in the primary prevention of hepatocellular carcinoma.
- Observed effects on adipose tissue and liver, with consideration of sex-based differences.
Conclusions:
- Aspirin demonstrates potential as a "hepatologic drug" for MASLD.
- Novel findings warrant further comprehensive investigation.
- Additional research is needed to fully elucidate aspirin's role in managing MASLD.
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