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Updated: Jun 26, 2025
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Characteristics and Risk Factors for Pediatric Sepsis
Yong-Bing Zhu1, Tong-Lin Liu1, Qi Dai1
1Department of Pediatric Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Insights
Predicting pediatric sepsis prognosis is crucial. Lower hemoglobin, albumin, platelet counts, and higher interleukin-1 beta levels indicate a poor outcome in children with sepsis.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Biomarkers and diagnostics
Background:
- Sepsis poses a significant threat to children, characterized by high mortality and morbidity.
- Current models for predicting pediatric sepsis prognosis are lacking reliability.
- Identifying risk factors is essential for timely intervention and improved outcomes.
Purpose of the Study:
- To analyze clinical characteristics of pediatric sepsis.
- To identify risk factors associated with poor prognosis in children with sepsis.
- To inform timely interventions for better patient outcomes.
Main Methods:
- Retrospective analysis of clinical indicators and laboratory results from pediatric sepsis patients.
- Inclusion of patients hospitalized in the Pediatric Intensive Care Unit from January 2019 to December 2021.
- Logistic regression analysis to identify risk factors for sepsis prognosis.
Main Results:
- 355 children with sepsis were analyzed; 6.2% had a poor prognosis.
- Poor prognosis was associated with longer hospital stays.
- Lower hemoglobin, albumin, platelet counts, and higher interleukin-1 beta levels were independent risk factors for poor prognosis.
Conclusions:
- Low hemoglobin, albumin, and platelet counts are significant indicators of poor prognosis in pediatric sepsis.
- Elevated interleukin-1 beta levels are also independently associated with adverse outcomes.
- These findings aid in identifying high-risk children for targeted management.
Objective:
Sepsis is considered a major cause of health loss in children and had high mortality and morbidity. Currently, there is no reliable model for predicting the prognosis of pediatric patients with sepsis. This study aimed to analyze the clinical characteristics of sepsis in children and assess the risk factors associated with poor prognosis in pediatric sepsis patients to identify timely interventions and improve their outcomes.
Methods:
This study analyzed the clinical indicators and laboratory results of septic patients hospitalized in the Pediatric Intensive Care Unit of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China, from January 1, 2019, to December 31, 2021. Risk factors for sepsis were identified by logistic regression analyses.
Results:
A total of 355 children with sepsis were enrolled, with 333 children (93.8%) in the good prognosis group, and 22 children (6.2%) in the poor prognosis group. Among them, there were 255 patients (71.8%) in the sepsis group, and 100 patients (28.2%) in the severe sepsis group. The length of hospital stay in the poor prognosis group was longer than that in the good prognosis group (P<0.01). The levels of interleukin 1β (IL-1β) in the poor prognosis group were higher than those in the good prognosis group (P>0.05), and the platelet (PLT), albumin (ALB), and hemoglobin (Hb) levels were lower in the poor prognosis group (P<0.01). The IL-8 levels in the severe sepsis group were higher than those in the sepsis group (P<0.05). Multiple logistic regression analysis suggested that lower Hb levels, ALB levels, peak PLT counts, and higher IL-1β levels were independent risk factors for poor prognosis in children with sepsis.
Conclusion:
Lower Hb, ALB, and PLT counts and elevated IL-1β are independent risk factors for poor prognosis in children with sepsis.
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