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Atrial Fibrillation After Coronary Artery Bypass Grafting and Its Relationship with Hospital Complications in São
Adnaldo da Silveira Maia1, Dayara Hoffmann Mayer2, Renê Augusto Gonçalves E Silva3
1Department of Cardiovascular Surgery, Instituto Dante Pazzanese de Cardiologia (IDPC), São Paulo, São Paulo, Brazil.
Insights
Postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) increases mortality and complications like pneumonia and sepsis. Early identification of POAF is crucial for better patient outcomes in cardiovascular surgery.
Area of Science:
- Cardiology
- Cardiac Surgery
- Critical Care Medicine
Background:
- Postoperative atrial fibrillation (POAF) is a common complication following cardiovascular surgery.
- Its multifactorial genesis necessitates prompt identification to mitigate associated risks.
Purpose of the Study:
- To determine the incidence of POAF in patients undergoing coronary artery bypass grafting (CABG).
- To investigate the association between POAF and other postoperative complications in this patient cohort.
Main Methods:
- A multicenter, observational study utilizing data from the REPLICCAR II registry (2017-2019).
- Inclusion of patients undergoing isolated CABG, with data prospectively collected via REDCap.
- Propensity score matching used to create comparable groups (POAF vs. no POAF) for analysis.
Main Results:
- Out of 3,803 patients, 605 developed POAF.
- POAF group (n=605) showed higher mortality (9.26%), prolonged ventilation, increased pneumonia, and sepsis rates compared to the non-POAF group.
- Multiple analysis linked POAF to acute renal dysfunction and extended intensive care unit (ICU) stay.
Conclusions:
- POAF in CABG patients is significantly associated with adverse outcomes.
- These include longer ICU and hospital stays, increased risk of renal dysfunction, pneumonia, and in-hospital mortality.
Introduction:
Atrial fibrillation is the main complication in the postoperative period of cardiovascular surgery. Its genesis is multifactorial, so its rapid identification to mitigate the associated risks is essential.
Objective:
To evaluate the incidence of atrial fibrillation in patients undergoing coronary artery bypass grafting (CABG) and its relationship with other complications in our setting.
Methods:
This is a multicenter, observational study involving patients undergoing isolated CABG between 2017 and 2019 with data from the Registro Paulista de Cirurgia Cardiovascular (or REPLICCAR II). Variables were prospectively collected in REDCap following the definitions given by version 2.73 of the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Data were collected with prior authorization from the local ethics committee and analyses performed in R software.
Results:
A total of 3,803 patients were included, of these 605 had postoperative atrial fibrillation (POAF). In order to adjust the groups, propensity score matching was used. Such analyses resulted in 605 patients in each group (without POAF vs. with POAF). Among patients with POAF, the mean age was 67.56 years, with a prevalence of males (73.6%, 445 patients). Patients belonging to the group with POAF had a mortality rate of 9.26% (P=0.007), longer ventilation time (P<0.001), pneumonia (P<0.001), and sepsis (P<0.001). In multiple analysis, acute renal dysfunction (P=0.032) and longer intensive care unit stay (P<0,001) were associated with the presence of POAF.
Conclusion:
POAF in CABG is associated with longer intensive care unit and hospital stay, as well as renal dysfunction, pneumonia, and in-hospital mortality.
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