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What is the optimum post treatment surveillance imaging protocol for low-grade appendiceal mucinous neoplasms and
Philip J Dempsey1, Jack W Power1, Andrew H Yates1
1Department of Radiology, Mater Misericordiae University Hospital, Dublin, D07, Ireland.
Abstract:
Appendiceal mucinous neoplasms are rare and can be associated with the development of disseminated peritoneal disease known as pseudomyxoma peritonei (PMP). Mucinous tumours identified on appendicectomy are therefore followed up to assess for recurrence and the development of PMP. In addition, individuals who initially present with PMP and are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) are followed up to assess for recurrence. However, despite the concerted efforts of multiple expert groups, the optimal imaging follow-up protocol is yet to be established. The purpose of this article is to review the available evidence for imaging surveillance in these populations to identify the optimum post-resection imaging follow-up protocol.
Insights
Optimal imaging surveillance protocols are needed for patients with appendiceal mucinous neoplasms and pseudomyxoma peritonei (PMP) post-surgery. This review examines current evidence to establish the best follow-up imaging strategy to detect recurrence.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Radiology
Background:
- Appendiceal mucinous neoplasms are rare tumors.
- These neoplasms can lead to pseudomyxoma peritonei (PMP), a disseminated peritoneal disease.
- Current follow-up imaging protocols for PMP and post-appendicectomy mucinous tumors lack standardization.
Purpose of the Study:
- To review existing evidence on imaging surveillance for patients with appendiceal mucinous neoplasms and PMP.
- To identify the optimal post-resection imaging follow-up protocol.
Main Methods:
- Systematic review of available literature on imaging surveillance in PMP and appendiceal mucinous neoplasm patients.
- Analysis of studies evaluating different imaging modalities and follow-up schedules.
- Synthesis of evidence to guide protocol development.
Main Results:
- Evidence for optimal imaging surveillance is limited and requires further investigation.
- Standardized protocols are crucial for early detection of recurrence and PMP development.
- Multidisciplinary expert consensus is needed to establish definitive guidelines.
Conclusions:
- There is a need for evidence-based imaging surveillance protocols for patients treated for appendiceal mucinous neoplasms and PMP.
- Further research is required to determine the most effective imaging modalities and follow-up intervals.
- Establishing optimal protocols will improve patient outcomes and resource utilization.
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