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Feasibility and operative outcomes of surgery in the liver area in advanced ovarian cancer

  • 0Department of Woman, Child, and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli, 00168 Rome, Italy; Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 00168 Rome, Italy.
Gynecologic Oncology +

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May 15, 2024

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May 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study classified ovarian cancer liver metastases using an anatomo-surgical system. Specific metastatic patterns correlate with distinct surgical outcomes and complication risks, aiding surgical planning.

Area Of Science

  • Oncology
  • Surgical Pathology
  • Hepatobiliary Surgery

Background

  • Advanced ovarian cancer frequently metastasizes to the liver.
  • Accurate classification of liver metastases is crucial for surgical planning and predicting outcomes.
  • Standardized classification systems can improve consistency in reporting complications.

Purpose Of The Study

  • To characterize intraoperative and postoperative complications associated with ovarian cancer liver metastases.
  • To evaluate the utility of a standardized anatomo-surgical classification system for these metastases.
  • To identify risk factors for severe complications based on metastatic patterns.

Main Methods

  • Retrospective analysis of 615 patients with ovarian cancer and perihepatic liver involvement (May 2016 - May 2022).
  • Classification of liver metastases into four categories: Class I (Peritoneal), Class II (Hepatoceliac-lymph-nodes), Class III (Parenchymal), and Class IV (Mixed).
  • Data collection included operative times, blood loss, transfusion rates, and specific intra- and postoperative complications.

Main Results

  • 15% intraoperative and 17.6% severe postoperative complications were observed.
  • Class II and IV were significantly associated with severe postoperative complications.
  • Independent risk factors for severe complications included Class II/IV involvement, high Surgical Complexity Score, and residual tumor.

Conclusions

  • Liver procedures in advanced ovarian cancer are feasible with manageable complication rates.
  • The anatomo-surgical classification effectively relates metastatic patterns to surgical outcomes and complication profiles.
  • This classification aids in predicting and managing complications in ovarian cancer patients with liver metastases.

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