Related Experiment Video
Updated: Jun 26, 2025

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Immunity by AS03ation: The natural adjuvantage
Lena Hansen1, Jenna J Guthmiller1
1Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Individuals respond differently to vaccines. Researchers found that high antibody responders to influenza vaccines naturally possess adjuvanted states, similar to those seen with AS03-adjuvanted vaccines, revealing key biological differences.
Area of Science:
- Immunology
- Vaccinology
- Biomedical Research
Background:
- Individual responses to vaccination vary significantly.
- Understanding these differences is crucial for improving vaccine efficacy.
- Adjuvants are known to enhance immune responses to vaccines.
Purpose of the Study:
- To investigate the biological factors underlying differential responses to unadjuvanted influenza vaccination.
- To identify characteristics of high antibody responders.
- To compare immune responses with and without adjuvants.
Main Methods:
- Development of a multimodal framework for analyzing immune responses.
- Characterization of immunophenotypes in vaccine responders.
- Comparative analysis of naturally adjuvanted states versus adjuvant-induced states.
Main Results:
- High responders to unadjuvanted influenza vaccine exhibited a naturally adjuvanted state.
- This natural state mimicked innate immunophenotypes observed after AS03-adjuvanted vaccination.
- Biological factors differentiate high-antibody responders.
Conclusions:
- Innate immune cues play a significant role in determining vaccine response.
- Adjuvants enhance humoral immunity by boosting these innate immune signals.
- Identifying naturally adjuvanted states offers insights into optimizing vaccine design.
More Related Videos
06:15Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
06:32Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Related Concept Videos
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...
Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Cells of the Adaptive Immune Response