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Advancements in nanoparticle-based therapies for multidrug-resistant candidiasis infections: a comprehensive review

Alireza Izadi1,2, Fatemeh Paknia3, Maryam Roostaee4

  • 1Department of Medical Parasitology and Mycology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Nanotechnology
|May 15, 2024
PubMed

Insights

Nanoparticle therapies show promise for treating multidrug-resistant Candida auris infections. This review highlights advancements in nanomaterials for combating this global fungal threat and improving patient outcomes.

Area of Science:

  • Mycology
  • Nanotechnology
  • Infectious Diseases

Background:

  • Candida auris is a rapidly emerging multidrug-resistant fungal pathogen with global health implications.
  • Conventional detection and treatment methods for C. auris infections are increasingly challenged by antifungal resistance.
  • The rise of multidrug-resistant fungal infections necessitates novel therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in nanoparticle-based therapies for fungal infections.
  • To emphasize the potential of nanomaterials in combating Candida auris infections.
  • To explore mechanisms of action and applications of nanomaterials against multidrug-resistant fungi.

Main Methods:

  • Literature review of recent studies on nanoparticle-based antifungal therapies.
  • Analysis of various nanomaterials including silver, carbon, zinc oxide, titanium dioxide, polymer, and gold.
  • Examination of mechanisms of action and combination strategies of nanomaterials.

Main Results:

  • Nanoparticle-based therapies demonstrate significant potential in treating cutaneous candidiasis.
  • Various nanomaterials show efficacy against multidrug-resistant fungal pathogens.
  • Combination therapies involving nanomaterials offer enhanced antifungal activity.

Conclusions:

  • Nanoparticle-based therapies represent a promising frontier in combating multidrug-resistant fungal infections, particularly Candida auris.
  • Further research into nanomaterial applications can lead to improved clinical outcomes and reduced mortality.
  • This approach offers a new era in targeted and effective antifungal interventions.
Keywords:
Candida aurisantifungal agentsdrug resistancemultidrug-resistantnanoparticle-based therapies

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