Association of triglyceride-glucose index with adverse cardiovascular events in patients with established coronary...

Area of Science:

• Cardiology
• Metabolic Syndrome
• Inflammation Research

Background:

• Insulin resistance is a key factor in cardiovascular disease (CVD) development.
• The triglyceride-glucose (TyG) index is a reliable marker for assessing insulin resistance.
• Inflammation plays a significant role in the progression of coronary artery disease (CAD).

Purpose of the Study:

• To investigate the association between the TyG index and cardiovascular (CV) event risk.
• To explore this association in CAD patients stratified by inflammation status.
• To determine if the TyG index can improve risk prediction in this population.

Main Methods:

• Recruited 20,518 patients with angiographically proven CAD.
• Categorized patients by TyG index tertiles and high-sensitivity C-reactive protein (hsCRP) levels.
• Followed patients for a median of 3.1 years to record primary endpoint events (CV death, myocardial infarction, stroke).

Main Results:

• Elevated TyG index (T2 or T3) was associated with increased CV event risk after adjusting for confounders.
• The association between high TyG index and CV events was significant only in patients with hsCRP levels above the median.
• The TyG index significantly improved risk prediction models for patients with higher inflammation levels.

Conclusions:

• Elevated TyG index is associated with increased CV event risk in CAD patients.
• This association is more pronounced in patients with higher inflammatory status (elevated hsCRP).
• The TyG index may serve as a valuable tool for risk stratification and prognosis in CAD patients, especially those with inflammation.