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Diabetic autonomic neuropathy.

B F Clarke, D J Ewing, I W Campbell

    Diabetologia
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic autonomic neuropathy affects multiple body systems, with metabolic causes likely. New diagnostic tests are emerging, but understanding its progression and impact on mortality requires further research.

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    Area of Science:

    • Neurology
    • Endocrinology
    • Diabetology

    Background:

    • Diabetic autonomic neuropathy (DAN) is increasingly recognized, but its precise mechanisms and lesion localization remain unclear.
    • Clinical manifestations span cardiovascular, gastrointestinal, urogenital, and thermoregulatory systems, with potential neuroendocrine and respiratory impacts yet to be fully defined.

    Purpose of the Study:

    • To review the current understanding of diabetic autonomic neuropathy, focusing on clinical features, pathogenesis, diagnostic approaches, and clinical implications.
    • To highlight the need for improved diagnostic tools and further research into the natural history and mortality associated with DAN.

    Main Methods:

    • Review of existing literature on diabetic autonomic neuropathy.
    • Analysis of clinical observations and postulated metabolic causation.

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  • Evaluation of current and emerging diagnostic tests for autonomic nerve function.

    • Main Results:

    • DAN involves multiple organ systems, with metabolic factors likely playing a key role in pathogenesis.
    • New diagnostic tests focusing on cardiovascular reflexes are being developed for precise quantification and diagnosis.
    • Abnormal autonomic function tests typically persist, and symptomatic DAN is associated with significantly increased mortality.

    Conclusions:

    • Diabetic autonomic neuropathy is a complex complication with widespread systemic effects.
    • Advancements in diagnostic testing are crucial for accurate diagnosis and management.
    • Further research is needed to elucidate the natural history, progression, and precise mortality risks associated with DAN.