Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Experimental RNAi02:15

Experimental RNAi

6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
RNA Interference01:23

RNA Interference

26.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.0K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tauroursodeoxycholate improves zoledronate-induced vascular endothelial dysfunction by suppressing the GCN2/eIF2α and IRE1/JNK pathways: a potential treatment option for MRONJ.

Acta biochimica et biophysica Sinica·2026
Same author

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

BMC oral health·2026
Same author

Comparative efficacy and safety of different treatment strategies for primary advanced ovarian cancer: a systematic review and network meta-analysis of randomized control trials.

Frontiers in oncology·2026
Same author

A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

Discover oncology·2026
Same author

Lactate dehydrogenase inhibitors: A promising candidate against aging and fibrosis.

European journal of medicinal chemistry·2025
Same author

Osteoinductive and Piezoelectrically Malleable Nanocomposite Bone Graft.

ACS nano·2025

Related Experiment Video

Updated: Jun 26, 2025

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay
08:26

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

Published on: April 12, 2018

8.0K

Non-coding RNA in infantile hemangioma.

Qizhang Wang1, Chengzhi Zhao1, Qianxin Du1

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Pediatric Research
|May 15, 2024
PubMed
Summary

Non-coding RNAs (ncRNAs) are critical in infantile hemangioma (IH) development. This review details known ncRNAs (miRNAs, lncRNAs, circRNAs) and explores potential roles for others in IH pathogenesis.

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.6K
Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

9.2K

Related Experiment Videos

Last Updated: Jun 26, 2025

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay
08:26

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

Published on: April 12, 2018

8.0K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.6K
Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

9.2K

Area of Science:

  • Vascular Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • Infantile hemangioma (IH) is the most common infant vascular tumor, with incompletely understood pathogenesis.
  • CD133+ stem cells are implicated in IH proliferation and development.
  • Key molecular pathways include HIF-1α, RAS, and VEGF, with non-coding RNAs (ncRNAs) emerging as crucial players.

Purpose of the Study:

  • To review and synthesize current knowledge on the role of ncRNAs in infantile hemangioma.
  • To identify specific ncRNAs (miRNAs, lncRNAs, circRNAs) involved in IH pathogenesis.
  • To highlight potential roles for other ncRNAs in IH.

Main Methods:

  • Comprehensive literature review of studies on ncRNAs and infantile hemangioma.
  • Analysis of published data on miRNAs, lncRNAs, and circRNAs in IH.
  • Discussion of potential functions of other ncRNA classes (snRNAs, snoRNAs, tsRNAs) in IH.

Main Results:

  • Identified specific miRNAs, lncRNAs, and circRNAs previously reported in infantile hemangioma.
  • Highlighted the critical roles of these ncRNAs in IH pathogenesis.
  • Noted that other ncRNAs, such as snRNAs, snoRNAs, and tsRNAs, warrant further investigation in IH.

Conclusions:

  • Non-coding RNAs are integral to the pathogenesis of infantile hemangioma.
  • Further research into ncRNAs, aided by advanced sequencing and bioinformatics, will enhance understanding of IH.
  • This review provides a foundation for future studies and potential therapeutic target identification in IH.