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Updated: Jun 26, 2025

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
Published on: August 14, 2021
The hidden threat: Unraveling the impact of microplastics on reproductive health
Mei Wang1, Ying Wu1, Guigui Li1
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, PR China; Hubei Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health, Wuhan 430071, Hubei, PR China; Wuhan Clinical Research Center for Reproductive Health and Optimal Birth, Wuhan 430071, Hubei, PR China.
Abstract:
Microplastics, with intricate physical and chemical characteristics, infiltrate the food chain and extensively impact ecosystems. Despite acknowledging the link between environmental pollution and declining fertility, the specific mechanisms affecting reproductive health remain to be elucidated. This review emphasizes the global correlation between microplastics and subfertility, focusing on entry pathways and impacts on ecosystems. Research suggests that microplastics disrupt the neuroendocrine system, influencing sex hormone synthesis through the hypothalamic-pituitary-gonadal (HPG) axis. In the reproductive system, microplastics interfere with the blood-testis barrier, impairing spermatogenesis in males, and causing placental dysfunction, ovarian atrophy, endometrial hyperplasia, and fibrosis in females. Moreover, microplastics potentially affect offspring's lipid metabolism and reproductive functions. However, complex microplastic compositions and detection method limitations impede research progress. Mitigation strategies for reproductive effects, combined with addressing microplastic pollution through sustainable practices, are imperative. This review underscores the urgency of global initiatives and collaborative research to safeguard reproductive health amid escalating microplastic contamination.
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