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Updated: Jun 26, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Down regulation of C1q tumor necrosis factor-related protein 6 is associated with increased risk of breast cancer
Samia F Hamed1, Nivin A Hassan2, Samia A Shouman3
1Cancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Circulating C1q tumor necrosis factor-related protein 6 (CTRP6) is decreased in breast cancer (BC) patients. Lower CTRP6 levels correlate with increased inflammatory markers and angiogenesis, suggesting CTRP6 as a potential diagnostic biomarker for BC.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- C1q tumor necrosis factor-related protein 6 (CTRP6) is implicated in various cancers, but its role in breast cancer (BC) remains unclear.
- Understanding CTRP6 expression and function in BC is crucial for identifying new diagnostic markers and therapeutic targets.
Purpose of the Study:
- To investigate circulating CTRP6 levels in BC patients.
- To evaluate CTRP6 as a potential diagnostic biomarker for BC.
- To elucidate the effect of CTRP6 on breast cancer cell viability and inflammatory/angiogenic markers.
Main Methods:
- Quantification of circulating CTRP6 levels in BC patients.
- Analysis of correlations between CTRP6, IL-6, TNF-α, and VEGF.
- Receiver Operating Characteristic (ROC) curve analysis for diagnostic prediction.
- In vitro studies using MCF-7 cells treated with recombinant CTRP6.
Main Results:
- Circulating CTRP6 levels were significantly decreased in BC patients.
- CTRP6 expression inversely correlated with IL-6, TNF-α, and VEGF levels.
- ROC curve analysis indicated CTRP6's potential as a BC diagnostic biomarker.
- Recombinant CTRP6 reduced MCF-7 cell viability and suppressed IL-6, TNF-α, and VEGF expression.
Conclusions:
- CTRP6 plays a role in breast cancer pathogenesis.
- Decreased CTRP6 levels are associated with BC progression and inflammation.
- CTRP6 holds promise as a novel diagnostic biomarker for breast cancer.
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