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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Jun 26, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

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Single-cell technologies in psoriasis.

Niannian Cui1, Xiaoqing Xu2, Fusheng Zhou2

  • 1First School of Clinical Medicine, Anhui Medical University, Hefei 230032, China.

Clinical Immunology (Orlando, Fla.)
|May 16, 2024
PubMed
Summary
This summary is machine-generated.

Single-cell technologies reveal immune cell roles in psoriasis, a chronic inflammatory skin disease. Understanding these cellular interactions advances knowledge of psoriasis onset and recurrence mechanisms.

Keywords:
Immune cellImmune microenvironmentMulti-omicsPathogenesisPsoriasisSingle-cell

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Establishing a High Throughput Epidermal Spheroid Culture System to Model Keratinocyte Stem Cell Plasticity
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Area of Science:

  • Immunology
  • Dermatology
  • Genomics

Background:

  • Psoriasis is a chronic inflammatory skin disorder.
  • The immune microenvironment is key to psoriasis, but cellular functions are unclear.

Purpose of the Study:

  • To review single-cell technology applications in psoriasis research.
  • To enhance understanding of psoriasis pathogenesis and recurrence.

Main Methods:

  • Single-cell transcriptome, proteome, and metabolome analysis.
  • Identification of heterogeneous cell clusters and their disease contributions.

Main Results:

  • Single-cell multi-omics enable detailed study of immune and parenchymal cell interactions.
  • These methods help identify cellular drivers of psoriasis.

Conclusions:

  • Single-cell technologies are crucial for elucidating psoriasis mechanisms.
  • Further exploration of immune cell functions will advance psoriasis treatment strategies.