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Efficiency of therapeutic plasma exchange in critically ill systemic rheumatologic diseases: A single-center 9-year
Jing Guo1,2,3, Xiaolong Huang1,2,3, Jianhua Li1,2,3
1Department of Intensive Care Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Introduction:
Therapeutic plasma exchange (TPE), an effective method to eliminate harmful soluble mediators associated with tissue injury, serves as a crucial intervention for systemic rheumatologic diseases (SRDs). However, its value in critically ill SRDs remains uncertain. This retrospective study aims to evaluate the efficacy of TPE in SRDs.
Methods:
Critically ill SRD patients admitted to the department of intensive care unit of a large tertiary hospital receiving TPE from January 2011 to December 2019 were included.
Results:
A total of 91 critically ill SRD patients received TPE were enrolled. Their mean age was 47.67 ± 16.35 years with a female predominance (n = 68). Significant decrease in SOFA score post-TPE treatment was observed (p < 0.05). There were no TPE-related fatalities. Improvement was observed in 64 (70.32%) patients.
Conclusion:
This study shows favorable clinical outcomes. TPE may be an acceptable treatment option for critically ill SRD patients.
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