Antimicrobial resistance pattern of Uro-Pathogens emphasizing non-lactose fermenting gram negative bacilli

Area of Science:

• Medical Microbiology
• Infectious Diseases
• Clinical Diagnostics

Background:

• Urinary tract infections (UTIs) are common, with Gram-negative bacilli being frequent causative agents.
• Non-lactose fermenting Gram-negative bacilli, such as Pseudomonas aeruginosa, pose treatment challenges due to antimicrobial resistance.

Purpose of the Study:

• To identify species of non-lactose fermenting Gram-negative bacilli causing UTIs.
• To determine the antimicrobial resistance patterns of these identified pathogens.

Main Methods:

• A retrospective, descriptive, cross-sectional study analyzed urine sample data from January 2020 to December 2021.
• Data from 103,887 urine samples were collected from a diagnostic laboratory and analyzed using SPSS version 25.

Main Results:

• Of 41,280 positive urine cultures, common Gram-negative lactose fermenters included Escherichia coli and Klebsiella pneumoniae.
• Pseudomonas aeruginosa, a non-lactose fermenting Gram-negative bacillus, was identified.
• Pseudomonas aeruginosa exhibited high resistance to tobramycin (79.3%) but lower resistance to piperacillin-tazobactam (13%).

Conclusions:

• Piperacillin-tazobactam demonstrated high sensitivity against non-lactose fermenting Gram-negative uro-pathogens.
• This finding suggests piperacillin-tazobactam as a potentially effective treatment option for UTIs caused by these resistant bacteria.