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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
518
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

901
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

709
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
709
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.2K
Overview
68.2K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Mitochondria Of T Lymphocytes Promote Anti-pulmonary Tumor Immune Response

Mitochondria of T Lymphocytes Promote Anti-Pulmonary Tumor Immune Response

Minsuk Kim1

  • 1Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul 07804, Korea.

World Journal of Oncology
|May 16, 2024

Related Experiment Videos

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
07:57

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

3.8K

View abstract on PubMed

Summary
This summary is machine-generated.

Cancer cells expel mitochondria when treated with Bcl-2 inhibitors. Tumor cells hijack T cell mitochondria, enhancing granzyme B-induced cell death and boosting anticancer immunity.

Area of Science:

  • Cell Biology
  • Cancer Research
  • Immunology

Background:

  • B-cell lymphoma 2 (Bcl-2) protein is implicated in apoptosis and cancer.
  • Advancements in optical technology allow real-time observation of subcellular organelles like mitochondria.
  • This study investigates mitochondrial dynamics in cancer cells and their regulation by Bcl-2.

Purpose of the Study:

  • To examine mitochondrial movement in cancer cells.
  • To correlate mitochondrial dynamics with Bcl-2 regulation.
  • To explore novel therapeutic strategies targeting mitochondria in cancer.

Main Methods:

  • Utilized a tomographic microscope for real-time observation of lung tumor cells.
  • Recorded holographic images of cells exposed to a laser beam (520 nm).
Keywords:
MitochondriaPulmonary fibroblast tumorRefractive indexTomographic microscope

Related Experiment Videos

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
07:57

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

12.2K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

3.8K
  • Investigated the effects of Bcl-2 and B-cell lymphoma extra-large (Bcl-xL) inhibitors on mitochondrial expulsion.

    • Main Results:

    • Lung tumor cells rapidly expelled mitochondria upon inhibitor treatment.
    • Tumor cells were observed hijacking mitochondria from T cells.
    • Hijacked mitochondria aided granzym B-induced tumor cell death, especially when T cells were depleted of Bcl-2 and Bcl-xL.

    Conclusions:

    • Modified T cell mitochondria enhance granzyme B-mediated tumor cell death.
    • Co-culturing tumor cells with T cells depleted of Bcl-2 and Bcl-xL improved anticancer immune response.
    • Targeting T cell mitochondria offers a potential novel strategy for cancer therapy.
    Tunneling nanotube