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HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis
Published on: June 24, 2019
Natural products' antiangiogenic roles in gynecological cancer
Shangmei Jia1, Ling Li1,2, Chenghao Yu1
1State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Abstract:
Gynecological cancers pose a significant threat to women's health. Although the pathogenesis of gynecological cancer remains incompletely understood, angiogenesis is widely acknowledged as a fundamental pathological mechanism driving tumor cell growth, invasion, and metastasis. Targeting angiogenesis through natural products has emerged as a crucial strategy for treating gynecological cancer. In this review, we conducted comprehensive searches in PubMed, Embase, Web of Science, Science Direct, and CNKI databases from the first publication until May 2023 to identify natural products that target angiogenesis in gynecologic tumors. Our findings revealed 63 natural products with anti-angiogenic activity against gynecological cancer. These results underscore the significance of these natural products in augmenting their anticancer effects by modulating other factors within the tumor microenvironment via their impact on angiogenesis. This article focuses on exploring the potential of natural products in targeting blood vessels within gynecological cancer to provide novel research perspectives for targeted vascular therapy while laying a solid theoretical foundation for new drug development.
Insights
This review identifies 63 natural products with anti-angiogenic activity against gynecological cancer. These compounds offer potential for targeted vascular therapies and new drug development in women
Area of Science:
- Oncology
- Pharmacology
- Natural Products Research
Background:
- Gynecological cancers represent a major health concern for women globally.
- Angiogenesis, the formation of new blood vessels, is a critical process in the growth, invasion, and metastasis of gynecological tumors.
- Targeting angiogenesis using natural products is a promising therapeutic strategy for gynecological cancer.
Purpose of the Study:
- To systematically review and identify natural products exhibiting anti-angiogenic properties against gynecological cancers.
- To explore the potential of these natural products in targeted vascular therapy for gynecological malignancies.
- To provide a theoretical foundation for the development of novel anti-cancer drugs derived from natural sources.
Main Methods:
- Comprehensive literature searches were conducted in major scientific databases (PubMed, Embase, Web of Science, Science Direct, CNKI) up to May 2023.
- Studies focusing on natural products with anti-angiogenic effects on gynecological tumors were included.
- Identified natural products were analyzed for their mechanisms of action and therapeutic potential.
Main Results:
- A total of 63 natural products demonstrating anti-angiogenic activity against gynecological cancer were identified.
- These natural products modulate angiogenesis, thereby impacting tumor growth, invasion, and metastasis.
- The findings highlight the role of these compounds in influencing the tumor microenvironment.
Conclusions:
- Natural products with anti-angiogenic effects represent a significant resource for developing novel treatments for gynecological cancers.
- Targeting tumor angiogenesis with these compounds offers a promising avenue for developing targeted vascular therapies.
- This review lays the groundwork for future research into natural product-based drug development for gynecological malignancies.
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