Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research progress on plant-based protein Pickering particles: Stabilization mechanisms, preparation methods, and application prospects in the food industry.

Food chemistry: X·2024
Same author

Direct 4D printing of ceramics driven by hydrogel dehydration.

Nature communications·2024
Same author

Improved capacitive energy storage performance in hybrid films with ultralow aminated molybdenum trioxide integration for high-temperature applications.

Materials horizons·2024
Same author

Efficacy and safety of Lianhua Qingwen as an adjuvant treatment for influenza in Chinese patients: A meta-analysis.

Medicine·2024
Same author

Correlation of 20 Single-Nucleotide Polymorphisms with Weight and Wool Traits in Alpine Merino Sheep.

Animals : an open access journal from MDPI·2024
Same author

Phase-Dependent Phonon Heat Transport in Nanoscale Gallium Oxide Thin Films.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same journal

Mind the gender gap: how defining head trauma increases reporting in women aged 30-50.

Frontiers in neurology·2026
Same journal

Traditional Chinese medicine interventions for post-stroke cognitive impairment: an evidence mapping.

Frontiers in neurology·2026
Same journal

Acupuncture is independently associated with improved recovery in Guillain-Barré syndrome: a prospective observational study.

Frontiers in neurology·2026
Same journal

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders.

Frontiers in neurology·2026
Same journal

Lumbar puncture opening pressure, brain network hub integrity, and delirium in herpes simplex virus encephalitis: a prospective cohort study.

Frontiers in neurology·2026
Same journal

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.

Frontiers in neurology·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

Assessing brain microstructural changes in chronic kidney disease: a diffusion imaging study using multiple models.

Limei Han1,2, Jie Yang2, Chao Yuan2

  • 1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.

Frontiers in Neurology
|May 16, 2024
PubMed
Summary
This summary is machine-generated.

Advanced MRI diffusion models effectively detect brain microstructural changes in chronic kidney disease (CKD) patients. These findings offer crucial insights into CKD-related neurological alterations.

Keywords:
brain microstructurechronic kidney diseasediffusion tensor imagingmean apparent propagator magnetic resonance imagingneurite orientation dispersion and density imaging

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.5K

Related Experiment Videos

Last Updated: May 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.5K

Area of Science:

  • Neuroimaging
  • Radiology
  • Nephrology

Background:

  • Chronic kidney disease (CKD) is associated with systemic complications, including potential neurological damage.
  • Understanding brain microstructural changes in CKD is crucial for comprehensive patient management.

Purpose of the Study:

  • To evaluate the efficacy of advanced diffusion magnetic resonance imaging (dMRI) models in identifying brain microstructural alterations in CKD patients.
  • To compare the diagnostic performance of different dMRI models for detecting CKD-related brain changes.

Main Methods:

  • Diffusion Spectrum Imaging (DSI) was performed on 44 CKD patients and 35 healthy controls.
  • Advanced dMRI models, including Diffusion Tensor Imaging (DTI), Neurite Orientation Dispersion and Density Imaging (NODDI), and Mean Apparent Propagator (MAP)-MRI, were reconstructed.
  • Tract-Based Spatial Statistics (TBSS) and Receiver Operating Characteristic (ROC) curve analyses were used to assess microstructural differences and diagnostic performance.

Main Results:

  • Significant differences in DTI, NODDI, and MAP-MRI parameters were observed between CKD patients and controls.
  • CKD patients showed decreased Fractional Anisotropy (FA) and increased Mean/Radial Diffusivity (MD/RD) via DTI.
  • NODDI revealed altered Intracellular/Extracellular Volume Fractions (ICVF/ECVF), while MAP-MRI indicated widespread microstructural changes, including elevated Mean Squared Displacement (MSD) and Q-space Inverse Variance (QIV).
  • MAP-MRI's Axial Non-Gaussianity (NGAx) demonstrated high diagnostic performance (AUC=0.843) in detecting CKD-related brain changes.

Conclusions:

  • Advanced dMRI models (DTI, NODDI, MAP-MRI) are effective in detecting brain microstructural changes in CKD.
  • These models provide valuable insights into the neurological impact of CKD, highlighting specific affected brain regions.