Vaccinomics and adversomics: key elements for a personalized vaccinology

Area of Science:

• Vaccinology
• Immunology
• Genetics

Background:

• Vaccines are crucial for infectious disease prevention, but vaccine hesitancy is a global challenge.
• Current vaccination strategies use uniform formulations and schedules for all individuals.
• A personalized approach to vaccinology is needed to enhance vaccine efficacy and safety.

Purpose of the Study:

• To review current knowledge on vaccinomics and adversomics.
• To explore genetic and non-genetic factors influencing individual vaccine responses.
• To highlight the potential of personalized vaccinology in overcoming vaccine hesitancy.

Main Methods:

• Literature review of recent scientific knowledge.
• Focus on genetic and non-genetic factors influencing immune response.
• Analysis of factors contributing to vaccine side effects.

Main Results:

• Vaccinomics and adversomics offer insights into individual variability in vaccine response.
• Genetic and non-genetic factors significantly impact immune response and adverse events.
• Personalized vaccinology can potentially improve vaccine outcomes and public health.

Conclusions:

• Personalized vaccinology, informed by vaccinomics and adversomics, holds promise for improving vaccine efficacy and safety.
• Understanding individual differences is key to addressing vaccine hesitancy and optimizing vaccination strategies.
• Further research into genetic and non-genetic determinants will advance personalized vaccinology.