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Updated: Jun 26, 2025

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Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
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Construction of a streptavidin-based dual-localized DNAzyme walker for disease biomarker detection
Lingying Xia1,2, Junbo Chen2, Xiandeng Hou2
1Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. zhourongxing@163.com.
Abstract:
A dual-localized DNAzyme walker (dlDW) was constructed by utilizing multiple split DNAzymes with probes, and their substrates are separately localized on streptavidin and AuNPs, serving as walking pedals and tracks, respectively. Based on dlDW, biosensing platform was successfully constructed and showed great potential application in clinical disease diagnosis.

