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Updated: Jun 26, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins

Bangchen Wang1, Micah Schub2, Derrick L Robinson3

  • 1Department of Pathology, Duke University, Durham, NC, USA.

Ultrastructural Pathology
|May 16, 2024
PubMed

Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.

Keywords:
CryoglobulinemiaWaldenström macroglobulinemiaglomerulonephritisrenal biopsy

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