Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant Masses in a Non-Cirrhotic Liver: All That Look Epithelial Are Not Carcinoma.

Cureus·2026
Same author

Refractory pruritus in cholestatic drug-induced liver injury secondary to androgenic anabolic steroids: Plasmapheresis to the rescue.

Asian journal of transfusion science·2026
Same author

The Hepatic Histomorphology and Application of Ensemble Transfer Learning in Convolutional Neural Network Models in the Biopsies of Hepatic Langerhans Cell Histiocytosis.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same author

Recurrent Liver Failure due to <i>SCYL1</i> Deficiency: A Report of 2 Cases and a Review of the Literature.

Journal of clinical and experimental hepatology·2026
Same author

Evaluation and Comparison of Histopathological Parameters between Core Needle Biopsy and Subcapsular Wedge Liver Biopsy in Children with Biliary Atresia: A Cross-sectional Study.

Journal of Indian Association of Pediatric Surgeons·2026
Same author

Pathology of Progressive Familial Intrahepatic Cholestasis: An update.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026

Related Experiment Video

Updated: Jun 26, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K

Histopathologic Predictors for Locoregional Recurrence in Patients With Oral Squamous Cell Carcinoma - A

Satnam Singh Jolly1, Vidya Rattan1, Lingesh Parasuraman1

  • 1104, Unit of Oral and Maxillofacial Surgery, Oral Health Sciences Centre.

The Journal of Craniofacial Surgery
|May 16, 2024
PubMed
Summary
This summary is machine-generated.

Aggressive oral squamous cell carcinoma (OSCC) often recurs. Higher pathologic node stage, extranodal extension (ENE), and close resection margins (≤5 mm) significantly predict locoregional recurrence (LRR) in OSCC patients.

More Related Videos

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
07:43

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

9.6K
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

3.8K

Related Experiment Videos

Last Updated: Jun 26, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K
Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
07:43

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

9.6K
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

3.8K

Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Oral squamous cell carcinoma (OSCC) is characterized by aggressive behavior and high rates of locoregional recurrence (LRR).
  • LRR in OSCC significantly contributes to poor patient prognosis and survival outcomes.
  • Predicting LRR is crucial for effective treatment planning and patient management.

Purpose of the Study:

  • To investigate the predictive role of various histopathologic parameters in determining LRR in OSCC patients.
  • To identify key prognostic factors that correlate with the likelihood of locoregional recurrence after treatment for OSCC.

Main Methods:

  • Retrospective analysis of 58 OSCC patients treated between January 2018 and December 2022.
  • Evaluation of clinicopathologic features including depth of invasion, tumor stage, nodal stage, differentiation grade, perineural invasion, lymphovascular invasion, extranodal extension (ENE), and margin of resection.
  • Statistical correlation of histopathologic factors with LRR incidence.

Main Results:

  • Locoregional recurrence (LRR) was observed in 20 (34.4%) of the 58 OSCC patients within one year.
  • A statistically significant correlation was found between LRR and higher pathologic node stage (N), presence of extranodal extension (ENE), and closest margin of resection (≤5 mm).
  • Of the patients who experienced recurrence, 14 died within 24 months.

Conclusions:

  • Higher pathologic node stage, presence of ENE, and closest margin of resection (≤5 mm) are significant histopathologic predictors of LRR in OSCC.
  • These factors can serve as critical prognostic indicators for patient outcomes.
  • Treatment intensification for early-stage OSCC with these adverse features may enhance survival rates.