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Updated: Jun 26, 2025
08:26
Monitoring Stub1-Mediated Pexophagy
Published on: May 12, 2023
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Mammalian pexophagy at a glance.
Justyna Bajdzienko1, Anja Bremm1
1Goethe University Frankfurt, Medical Faculty , Institute of Biochemistry II, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Journal of Cell Science
|May 16, 2024
Summary
Mammalian pexophagy, the process of removing damaged peroxisomes, is crucial for cell health. This review highlights ubiquitylation
Area of Science:
- Cell Biology
- Organelle Biology
- Autophagy
Background:
- Peroxisomes are vital organelles regulating metabolism and redox balance.
- Their numbers dynamically adjust to nutrient and stress conditions.
- Pexophagy, or selective peroxisome autophagy, removes damaged or excess peroxisomes.
Purpose of the Study:
- To summarize current knowledge on mammalian pexophagy control.
- To identify areas needing further research in mammalian pexophagy.
- To discuss the role of ubiquitylation in pexophagy.
Main Methods:
- Review of current literature on mammalian pexophagy.
- Analysis of ubiquitylation pathways in pexophagy.
- Comparison of mammalian and yeast pexophagy mechanisms.
Main Results:
- Mammalian pexophagy is induced by ubiquitylation of peroxisomal proteins or ubiquitin-independent pathways.
- Dysregulation of pexophagy is linked to human diseases.
- Ubiquitin machinery plays a key role in recruiting phagophores to peroxisomes.
Conclusions:
- Understanding mammalian pexophagy is crucial for maintaining peroxisome homeostasis.
- Further research is needed to fully elucidate mammalian pexophagy mechanisms.
- Ubiquitylation is a central regulator of pexophagy.
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