Nanoencapsulation of a Far-Red Absorbing Phthalocyanine into Poly(benzylmalate) Biopolymers and Modulation of Their
Zeynel Şahin1, Emel Önal2, Lamiaa M A Ali3,4
1Faculty of Technology, Department of Metallurgical & Materials Engineering, Marmara University, 34722 Istanbul, Türkiye.
Abstract:
Two different poly(benzylmalate) biopolymers, a hydrophobic non-PEGylated (PMLABe) and an amphiphilic PEGylated derivative (PEG-), have been used to encapsulate a phthalocyanine chosen for its substitution pattern that is highly suitable for photodynamic therapy. Different phthalocyanine/(co)polymers ratios have been used for the nanoprecipitation. A set of six nanoparticles has been obtained. If the amphiphilic PEGylated copolymer proved to be slightly more efficient for the encapsulation and to lower the aggregation of the phthalocyanine inside the nanoparticles, it is, however, the hydrophobic PMLABe-based nanoparticles that exhibited the best photodynamic efficiency.
